Statin use lowers the risk of developing late-life parkinsonism

Takeaway

  • Use of statins, especially of moderate or high potency, is associated with a lower risk of parkinsonism in older adults. This may be partially mediated by a lower odds of cerebral atherosclerosis.  

Why this matters

  • Parkinsonian signs such as tremor or rigidity are seen in approximately 50% of older adults and are associated with adverse health outcomes including falls, disability, dementia, and mortality.

  • Statins may have a potential role in decreasing the magnitude of parkinsonism (2 or more parkinsonian signs) in an aging population.