Blocking CGRP for migraine therapy may help – or harm – host immunity against pathogens

Calcitonin gene-related peptide (CGRP) regulates pain, but its complex interaction with the immune system may have important clinical implications.

“Many types of infection are characterized by pain”, said Dr Isaac Chiu of Harvard Medical School in Boston, Massachusetts, USA, presenting at AHS 2021. Infection-induced pain was thought to arise from the stimulation of nociceptor neurons by inflammatory mediators like prostaglandins that are produced by immune cells in response to pathogens.